Multiscale Modeling of Protein Aggregation

eSMB2020 eSMB2020 Follow 2:30 - 3:30pm EDT, Monday - Wednesday
Share this

Suzanne Sindi

UC Merced
"Multiscale Modeling of Protein Aggregation"
Protein aggregation poses major health challenges for humans, but instead confer beneficial phenotypes for yeast. However, experiments on yeast systems necessarily involve multiple scales cell/colony. In this talk, I describe efforts towards linking these scales with mathematical models. More specifically, propagon counting assays reflect the intracellular amplification process of prion aggregation coupled with cell-division. We model these experiments with generation and aggregate structured population models. Through an inverse problem formulation we attempt to infer the intracellular replication rates of these aggregates.
Hosted by eSMB2020 Follow
Virtual conference of the Society for Mathematical Biology, 2020.