Legend / Color-coding:
- MEPI (Mathematical Epidemiology)
- CDEV (Cell and Developmental Biology)
- EDUC (Education)
- IMMU (Immunobiology and Infection)
- NEUR (Mathematical Neuroscience)
- MFBM (Methods for Biological Modeling)
- POPD (Population Dynamics, Ecology & Evolution)
- ONCO (Mathematical Oncology)
- OTHE (Other)
Coffee with friends & colleagues
Modulation of synchronization by a slowly varying M-current
The neurotransmitter acetylcholine has been shown to modulate the firing properties of several types of neurons through the down-regulation of voltage dependent potassium currents such as the muscarine-sensitive M-current. In the brain, levels of acetylcholine change with activity. For example, acetylcholine is higher during waking and REM sleep and low during slow wave sleep. In this talk we show how the M-current affects the bifurcation structure of a generic conductance-based neural model and how this determines synchronization properties of the model. We then use phase-model analysis to study the effect of a slowly varying M-current on synchronization. This is joint work with Victoria Booth, Xueying Wang and Isam Al-Darbasah.
Sub-group contributed talks (9:30-11:00am)
CDEV: The interplay of intracellular pattern formation, geometry, polarisation and mechanics (9:30-11:00am)
- Erwin Frey Ludwig-Maximilians University Munich "Self-organization principles of intracellular pattern formation"
- Veronica Grieneisen Cardiff University "Self-organization through the mesoscale, lessons from plant patterning and adaptive responses"
- Stan Maree Cardiff University "Intracellular patterning coupled to cell shape can lead to sensitization of signal detection"
- Padmini Rangamani University of California at San Diego "Stability analysis of a bulk-surface model for membrane-protein clustering"
IMMU: Subgroup Contributed Talks (9:30-11:00am)
- Shilian Xu Monash University "Saturation of influenza virus neutralization and antibody consumption can both lead to bistable growth kinetics"
- Jacob Summers University of Tennessee "Mathematical modeling of Mycobacterium tuberculosis dynamics in macaques"
- Suneet Singh Jhutty Frankfurt Institue for Advanced Studies (FIAS); Goethe University Frankfurt, Germany "Mapping Influenza from blood data using deep learning"
- Yuhuang Wu University of New South Wales, Sydney "Impact of fluctuation in frequency of HIV reactivation during antiretroviral therapy interruption"
- Vitaly Ganusov University of Tennessee "Structure-imposed constrains make Brownian walkers efficient searchers"
MEPI: Subgroup Contributed Talks (9:30-11:00am)
- Samson Ogunlade James Cook University "Modeling the potential of wAu-Wolbachia strain invasion in mosquitoes to control Aedes-borne arboviral infections"
- Maryam Aliee University of Warwick "Estimating the distribution of extinction times of infectious diseases in deterministic models"
- Sung-mok Jung Hokkaido University "Reconstruction and analysis of the transmission network of African swine fever in People’s Republic of China, August 2018–September 2019"
- Usman Sanusi Technical University of Munich "Influence of quiescence on host-parasite coevolutionary dynamics"
MFBM: Subgroup Contributed Talks (9:30-11:00am)
- Fiona Macfarlane University of St. Andrews, Scotland, email@example.com "Bridging the gap between individual-based and continuum models of growing cell populations"
- Alexey Penenko ICM&MG SB RAS, Russian Federation, firstname.lastname@example.org "Inverse Modeling of Biological Processes with Adjoint Ensemble Methods"
- Karina Islas Rios Monash University Australia email@example.com "NetScan: a computational tool for discovering and visualizing biochemical networks with defined topological structures."
- Hyukpyo Hong Korea Advanced Institute of Science and Technology, Republic of Korea, firstname.lastname@example.org "Derivation of stationary distributions of biochemical reaction networks via structure transformation"
- Linard Hoessly University of Copenhagen, Denmark, email@example.com "Stationary distributions of stochastic reaction networks via decomposition"
NEUR: Rhythms, Sleep, Reward, Vision (9:30-11:00am)
- Kevin Hannay University of Michigan "Circadian State Estimation using Wearable Data"
- Maia Angelova Deakin University "Data driven model for detecting insomnia from multi-night actigraphy time series data"
- Davide Maestrini UCLA "A mathematical model of 'wanting', 'liking, and brain reward circuitry in drug addiction"
- Paul Roberts University of Sussex "Using mathematics to investigate the mechanisms behind vision loss"
ONCO: Subgroup Contributed Talks (9:30-11:00am)
- Ryan John Murphy Queensland University of Technology, Australia "Mechanical cell competition in heterogeneous epithelial tissues"
- Aleksandra Ardaseva University of Oxford, Oxford, UK "Modelling evolutionary adaptation of cancer cells to fluctuating oxygen levels"
- Phillip J. Brown The University of Adelaide, Australia "Modelling colon cancer: Investigating serrated crypts using a new model for deformable membranes"
- Lisa C. Tucker-Kellog Singapore "During multi-drug combination therapy, the speed of evolving drug-resistance is affected by the uniformity of pairwise synergism, additivity, or antagonism between the drugs"
- Yangjin Kim Konkuk University, Republic of Korea "How the surgery-induced transition of reactive astrocytes to stem cell-like phenotypes leads to recurrence of GBM by Cxcl5: hybrid multi-scale approaches"
OTHE: Other Contributed Talks (9:30-11:00am)
- Josephine Solowiej-Wedderburn Surrey "Sensing some resistance: A mathematical model for the contractile mechanosensory mechanism within cells"
- Ashlee N. Ford Versypt Oklahoma State "Investigation of Short Chain Fatty Acids on the Gut-Bone Axis: From Mechanism to a Computational Systems Approach"
- Shaza Alsibaai McGill University "Mathematical Modeling of Human Erythropoiesis"
- Torbjörn Lundh Gothenburg "Möbius invariances in biology"
- Jessica Crawshaw U. Melbourne "Examining the mechanical forces driving vascular regression using a fluid-structure-growth model"
POPD: Subgroup Contributed Talks (9:30-11:00am)
- Sharon Bewick Clemson University "Nested Metapopulations"
- Lihong Zhao University of Idaho "Eco-evolutionary Dynamics of Microbial Communities"
- Erida Gjini Instituto Gulbenkian de Ciência "A critical transition in N-strain co-colonization dynamics"
- Christel Kamp Paul-Ehrlich-Institut "Kinetic fingerprint of bacterial depletion indicates phage synergy"
- David Versluis Leiden University "Multiscale Modelling of the Colonic Microbiota in Infants"
15 minute break (11:00-11:15am)
Potent Neutralizing Monoclonal Antibodies Directed to Multiple Epitopes on the SARS-CoV-2 Spike
The SARS-CoV-2 pandemic rages on with devasting consequences on human lives and the global economy. The discovery and development of virus-neutralizing monoclonal antibodies could be one approach to treat or prevent infection by this novel coronavirus. Here we report the isolation of 61 SARS-CoV-2-neutralizing monoclonal antibodies from 5 infected patients hospitalized with severe disease. Among these are 19 antibodies that potently neutralized the authentic SARS-CoV-2 in vitro, 9 of which exhibited exquisite potency, with 50% virus-inhibitory concentrations of 0.7 to 9 ng/mL. Epitope mapping showed this collection of 19 antibodies to be about equally divided between those directed to the receptor-binding domain (RBD) and those to the N-terminal domain (NTD), indicating that both of these regions at the top of the viral spike are quite immunogenic. In addition, two other powerful neutralizing antibodies recognized quaternary epitopes that are overlapping with the domains at the top of the spike. Cyro-electron microscopy structures of one antibody targeting RBD, a second targeting NTD, and a third bridging two RBDs revealed recognition of the closed, “all RBD-down” conformation of the spike. Several of these monoclonal antibodies are promising candidates for clinical development as potential therapeutic and/or prophylactic agents against SARS-CoV-2.
Adam Martin, Massachusetts Institute of Technology, @martinlabmit
Cell & Developmental Biology Subgroup
Folding tissues across length scales: Cell-based origami
Throughout the lifespan of an organism, tissues are remodeled to shape organs and organisms and to maintain tissue integrity and homeostasis. Apical constriction is a ubiquitous cell shape change of epithelial tissues that promotes epithelia folding and cell/tissue invagination in a variety of contexts. Apical constriction promotes tissue bending by changing the shape of constituent cells from a columnar-shape to a wedge-shape. Drosophila gastrulation is one of the classic examples of apical constriction, where cells constrict to fold the primitive epithelial sheet and internalize cells that will give rise to internal organs. We have used a combination of imaging, experimental perturbation, and modeling, to determine how actomyosin organization promotes tissue folding. The actin cytoskeleton is organized in both time and space to facilitate apical constriction. We found that actomyosin contraction is pulsatile and requires dynamic regulation of upstream signaling processes. In addition, we found that actomyosin becomes organized into oriented fibers, which generates anisotropic tension that is critical for tissue shape. Furthermore, connectivity within the network of actomyosin fibers is highly redundant, promoting the robustness of folding.
Sub-group contributed talks (1:30-3:30pm)
CDEV: Integrating cell mechanics and cell mechanosensing (1:30-3:30pm)
- Ulrich Schwarz University of Heidelberg "Emergence of elasticity in cell mechanics"
- Fabian Spill University of Birmingham "Role of physical and geometrical drivers of tumour metastasis"
- Carina Dunlop University of Surrey "Cytoskeletal contractility in mechanosensing"
- Benedikt Sabass Forschungszentrum Juelich "Substrate durokinesis of the bacterium P. aeruginosa"
IMMU: Subgroup Contributed Talks (1:30-3:30pm)
- Sahak Makaryan University of Southern California "In Silico Control and Optimization of Granzyme B and Perforin-1 Secretion in Natural Killer Cells"
- Naveen Vaidya San Diego State University "HIV Infection and Antiretroviral Therapy: the Brain as a Reservoir"
- Cristina Leon RUDN University, Russia "Reaction-diffusion model of viruses coexistence in the space of genotypes"
- Mohammad Aminul Islam Oklahoma State University "Computational modeling of the gut-bone axis and implications of butyrate treatment on osteoimmunology"
- Georges Ferdinand Randriafanomezantsoa Radohery Kirby Institute, University of New South Wales, Sydney "Incorporating parasite viability data into PK/PD modelling of artemisinin treatment of human malaria"
MEPI: Subgroup Contributed Talks (1:30-3:30pm)
- (Speaker cancellation) N/A "(Speaker cancellation)"
- Folashade Agusto University of Kansas "To isolate or not to isolate: The impact of changing behavior on COVID-19 transmission"
- Alexander Beams University of Utah "Mask, or JASC? What are the conditions under which SARS-CoV-2 becomes Just Another Seasonal Coronavirus?"
- Juan Gutierrez University of Texas at San Antonio "Modeling COVID-19 Under Lockdown Conditions"
- Diego Volpatto Laboratorio Nacional de Computacao Cientifica "A Bayesian approach to assess the spread of COVID-19 using an extended SEIRD model with implicit quarantine mechanism: applications in Brazilian locations"
- Julie Spencer Los Alamos National Lab "Prioritizing Mitigation Strategies for COVID-19 in New Mexico"
MFBM: Subgroup Contributed Talks (1:30-3:30pm)
- David Hardman University of Edinburgh, Scotland, firstname.lastname@example.org "Optimising muscle cell co-culturing protocol through a combined in vitro-agent based modelling approach"
- Doris Schittenhelm Friedrich-Alexander-Universität Erlangen-Nürnberg Germany email@example.com "A Bayesian framework for parameter estimation from fluorescence data"
- Endre T Somogyi Indiana University Bloomington, United States, firstname.lastname@example.org "Real-Time Interactive, Scriptable 3D Simulation of Cell / Virus-Like-Particle Endocytosis With Tellurium / Mechanica"
- Patrick S. Eastham Florida State University, United States, email@example.com "A framework for simulating precipitate reactions in microfluidic devices"
- Anastasios Siokis Helmholtz Centre for Infection Research, Germany, firstname.lastname@example.org "An agent-based simulation platform studying the immunological synapse dynamics"
ONCO: Subgroup Contributed Talks (1:30-3:30pm)
- Noemi Andor Moffitt Cancer Center "Invasion of homogeneous and polyploid populations in nutrient-limiting environments?"
- Parthasakha Das IIEST, SHIBPUR, India "Optimal treatment strategies with multiple therapeutic approach in Cancer remission: A model based study"
- Anna K. Miller H. Lee Moffitt Cancer Center, Tampa USA "Modeling the spatiotemporal dynamics of the vicious cycle in multiple myeloma"
- Fabio A. Milner Arizona State University "A model for acute myeloid leukemia (AML)"
- Inmaculada C. Sorribes Duke University "Detailed quantitative framework of in silico xenografts implanted with high-grade gliomas reveals novel dosage schedule of several chemotherapeutic agents"
- Sara Hamis School of Mathematics and Statistics, University of St Andrews, St Andrews KY16 9SS, Scotland "Bridging in vitro and in vivo research via an agent-based modelling approach"
OTHE: Other Contributed Talks (1:30-3:30pm)
- Eleanor Doman UCL, London "Investigating the mechanical properties of peripheral nerve tissue using new biomechanical models"
- Julia Arciero IUPUI "Modeling blood flow regulation and tissue oxygenation in the retina"
- Peter Mortensen Glasgow "Action potential propagation in a myocyte-fibroblast model of cardiac tissue"
- Katarzyna Rejniak Moffitt Cancer Center "In silico tools for deconvolution of complex tumor microenvironments: Organoid3D and silicoDCIS"
- Ruben Perez-Carrasco Imperial "Effects of cell cycle variability on stochastic gene expression"
POPD: Subgroup Contributed Talks (1:30-3:30pm)
- Eva Kisdi University of Helsinki "The evolution of habitat choice facilitates niche expansion"
- Enpei Zhang University of Helsinki "Evolution of maturation time in a stage structure prey-predator model"
- Daniel Cooney Princeton University "PDE Models of Multilevel Selection: The Evolution of Cooperation and the Shadow of Individual Selection"
- Cecilia Berardo University of Helsinki "Evolution of density-dependent handling times in a predator-prey model."
- Maksim Mazuryn Technical University of Denmark "Diel Vertical Migration as a Mean Field Game"
Carl Bergstrom, University of Washington, @CT_Bergstrom
Misinfodemic 2020: How quantitative misinformation misleads the public about COVID-19, and what mathematical biologists can do about it.
Most people think they have pretty good bullshit detectors, at least when it comes to advertising hyperbole, weasel words, and politicians’ promises. Quantitative claims are harder: Numbers have the sense of objectivity and precision, and people feel less confident in challenging them. Yet with COVID-19, quantitative epidemiology is on the front page of every newspaper on every day of the week. Shortly before the pandemic broke out, I finished a book on how to spot and refute quantitative misinformation. Every lesson in the book has proven useful during the current pandemic. In this talk, I will present a tour of how misleading numbers, statistics, mathematics, and data graphics have muddied the social and traditional media streams that we all rely upon during COVID. I will give examples of deliberate disinformation, and examples of unintended misinformation around the pandemic. And I will explore how as citizens and as educators we all can promote data reasoning and quantitative literacy.